Why do some people, after contemplating the non-self of the five aggregates (pañca-skandha) to a certain point, begin to feel agitated and distressed, unable to continue their contemplative practice (vipaśyanā-caryā)? This is because the manas has somewhat sensed that the five aggregates are without self, that they are not real in themselves; He fears that there is truly no self, fears that He himself will disappear. This is precisely the result of the manas's habitual tendency of grasping at self, accumulated over beginningless kalpas. Having never previously encountered content such as non-self, now through the mind consciousness's deliberation, He understands a little, but not yet clearly; He fears that if the mind consciousness continues deliberating, He himself will cease to exist and can no longer be grasped, and so He becomes agitated and distressed, not allowing the mind consciousness to continue deliberating and contemplating.
From this phenomenon, it can be seen that the eradication of the view of self (satkāya-dṛṣṭi-prahāṇa) means eradicating the manas's view of self. Throughout the process of deep and subtle deliberation and contemplative practice, the manas participates; the manas knows all the content of the mind consciousness's deliberation and contemplation, and then He deliberates (manasikāra) on this content Himself. When the manas has been cultivated through permeation to a certain degree, He can completely understand the principle of non-self and the principle of the eighth consciousness, and afterward can realize it. The manas must certainly have the power of determination (adhimokṣa) with regard to the Buddha-dharma; otherwise the mind consciousness could not permeate and influence the manas, and studying Buddhism would be useless. After the manas is enlightened, He will gradually attain great wisdom, transform the consciousnesses into wisdom, attain the wisdom of equality (samatā-jñāna), and when wisdom is perfected, He becomes a Buddha.
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